منابع مشابه
PPARs in Alveolar Macrophage Biology
PPARs, most notably PPAR-gamma, play a crucial role in regulating the activation of alveolar macrophages, which in turn occupy a pivotal place in the immune response to pathogens and particulates drawn in with inspired air. In this review, we describe the dual role of the alveolar macrophage as both a first-line defender through its phagocytotic activity and a regulator of the immune response. ...
متن کاملPPARs in Lung Biology and Disease
In this special issue of PPAR Research, we have assembled a comprehensive and complementary group of review articles and original investigations that illustrate the pivotal role of the PPAR family of nuclear hormone receptors in the regulation of fundamental cellular events in the lung. The lung performs the vital function of gas exchange required for the delivery of oxygen to tissues. In perfo...
متن کاملPPARs in Eye Biology and Disease
Welcome to this special issue of PPAR research dedicated to " PPARs in Eye Biology and Disease. " PPARs are well known to regulate the expression of genes involved in lipid and glucose metabolism. Very recently, these transcription factors have been demonstrated to modulate proliferative, inflammatory, and oxidative stress responses, including those that happen in the eye. We have collected a c...
متن کاملSuppression of macrophage inflammatory responses by PPARs.
T he proinflammatory response of macrophages to stimuli, such as lipopolysaccharide (LPS) or IFN , can be blocked by ligands for peroxisome proliferator-activated receptors (PPARs). However, the mechanisms, and even the validity, of this antiinflammatory role for PPARs has recently come under question. The paper by Welch et al. (1) in this issue of PNAS addresses some of these concerns, and sug...
متن کاملThe alveolar macrophage.
The pulmonary macrophagic system is critical to the defense of the lung, keeping the alveoli clean and sterile and responding on demand with an adaptive outpouring of new cells into the air sacs. Under basal conditions alveolar macrophages, in common with other mononuclear phagocytes, are derived from the bone marrow. A population of macrophage precursors within the pulmonary interstitium provi...
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ژورنال
عنوان ژورنال: PPAR Research
سال: 2007
ISSN: 1687-4757,1687-4765
DOI: 10.1155/2007/23812